![]() ![]() However, lock-key model does not truly represent the real enzyme action, which would be more complex. Group discussion How is lock-key similar to enzyme action? Would you liken enzyme to a lock or a key? Why?ĥ Lock-key model is a science model to explain the specificity of enzyme action. Above all, adhering to Fischer’s original idea would be more appropriate. These arguments show that models often have limitations in showing the real natural phenomena. ![]() But some people later claim that enzyme is better likened to the key since it is not changed in the action. Fischer likened the enzyme to a lock and the substrate to a key since enzymes are often larger than substrates and its active site is always hidden inside the enzyme molecule. The specificity of the key-lock is a result of their complementary shapes, which is also a crucial feature between substrate and active site. This model illustrates the specificity of enzyme actions since one key can only open one specific lock. The key (substrate) fits in the key hole (active site) of the lock (enzyme). The development of science model needs a little of imagination: You had not really seen a substrate binding to the enzyme!Ĥ In 1894, Fischer first used lock and key to explain the action of enzymes - lock and key model Sometimes model is used the same as theory in science. What you observed What you think it may be like thatģ Science model A model in science is a simplified description and explanation of the natural process. Science model Explain to students that they have just used a science model to explain the enzyme action. Understanding how science works Victor Lau CUHK Presentation on theme: "From lock and key model to induced fit model"- Presentation transcript:ġ From lock and key model to induced fit model ![]()
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